Thomas R Kosten Selected Research

Cocaine-Related Disorders (Cocaine Addiction)

6/2022	Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.
1/2021	The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.
1/2019	Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.
1/2019	Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction.
1/2018	A Double-Blind, Placebo-Controlled Trial Demonstrating the Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336.
12/2017	Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials.
9/2014	Hapten optimization for cocaine vaccine with improved cocaine recognition.
7/2014	The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study.
7/2014	Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial.
4/2014	Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms.

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Thomas R Kosten Research Topics

Disease

65	Schizophrenia (Dementia Praecox) 01/2022 - 01/2002
44	Cocaine-Related Disorders (Cocaine Addiction) 06/2022 - 04/2002
27	Substance-Related Disorders (Drug Abuse) 03/2022 - 01/2002
26	Opioid-Related Disorders (Opiate Addiction) 01/2022 - 04/2002
16	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2021 - 01/2002
14	Tardive Dyskinesia 10/2013 - 05/2007
10	Cognitive Dysfunction 10/2016 - 07/2012
8	Alcoholism (Alcohol Abuse) 12/2017 - 09/2002
8	Tobacco Use Disorder (Nicotine Dependence) 11/2017 - 04/2002
6	Body Weight (Weight, Body) 01/2021 - 06/2007
5	Psychotic Disorders (Schizoaffective Disorder) 01/2019 - 07/2002
4	Weight Gain 01/2021 - 06/2007
4	Type 2 Diabetes Mellitus (MODY) 03/2019 - 04/2013
3	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022 - 08/2014
3	Paranoid Disorders (Paranoia) 04/2013 - 05/2005
2	Major Depressive Disorder (Major Depressive Disorders) 01/2020 - 08/2003
2	Mental Disorders (Mental Disorder) 10/2019 - 08/2013
2	Obesity 01/2018 - 12/2008
2	Heroin Dependence (Heroin Abuse) 05/2016 - 04/2004
2	Gambling (Pathological Gambling) 11/2015 - 10/2004
2	Diabetes Mellitus 08/2011 - 04/2011
2	Drug Overdose 01/2005 - 10/2002
2	Cardiotoxicity 02/2004 - 10/2002
1	Chronic Disease (Chronic Diseases) 03/2022
1	Hepatitis B 01/2022
1	Overweight 01/2021

Drug/Important Bio-Agent (IBA)

36	Cocaine (Cocaine HCl)IBA 01/2021 - 01/2002
23	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 06/2007
19	VaccinesIBA 03/2022 - 10/2002
18	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2016 - 12/2007
17	Methadone (Dolophine)FDA LinkGeneric 01/2018 - 01/2002
16	Pharmaceutical PreparationsIBA 01/2022 - 10/2002
16	Opioid Analgesics (Opioids)IBA 01/2021 - 07/2002
15	Buprenorphine (Subutex)FDA LinkGeneric 06/2022 - 01/2002
15	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 01/2002
14	Disulfiram (Antabuse)FDA Link 01/2021 - 04/2002
11	Opiate AlkaloidsIBA 12/2015 - 01/2002
11	EnzymesIBA 05/2014 - 05/2007
9	Naltrexone (ReVia)FDA LinkGeneric 11/2019 - 07/2003
9	CytokinesIBA 10/2019 - 07/2008
8	Free RadicalsIBA 10/2013 - 05/2007
7	Nicotine FDA Link 10/2019 - 04/2002
7	Superoxide DismutaseIBA 05/2014 - 05/2007
7	AntioxidantsIBA 10/2013 - 05/2007
6	Risperidone (Risperdal Consta)FDA LinkGeneric 10/2019 - 12/2007
6	Methamphetamine (Desoxyn)FDA LinkGeneric 10/2019 - 10/2008
6	Mixed Function Oxygenases (Monooxygenases)IBA 01/2019 - 02/2013
6	Clozapine (Clozaril)FDA LinkGeneric 01/2014 - 06/2007
5	Heroin (Diamorphine)IBA 05/2016 - 01/2002
3	Sertraline (Zoloft)FDA LinkGeneric 01/2022 - 12/2015
3	Fentanyl (Sublimaze)FDA LinkGeneric 05/2021 - 01/2018
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2020 - 09/2012
3	Interleukin-18 (Interleukin 18)IBA 01/2016 - 08/2012
3	Interleukin-2 (IL2)IBA 01/2016 - 05/2009
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/2014 - 02/2013
3	Dopamine beta-HydroxylaseIBA 07/2013 - 11/2003
3	Bupropion (Wellbutrin)FDA LinkGeneric 05/2007 - 07/2002
2	Naloxone Drug Combination Buprenorphine FDA Link 06/2022 - 09/2004
2	Genetic Markers (Genetic Marker)IBA 06/2022 - 02/2011
2	Aldehyde DehydrogenaseIBA 01/2022 - 01/2009
2	Exenatide (Byetta)FDA Link 01/2021 - 01/2018
2	Tropisetron (Navoban)IBA 01/2020 - 09/2012
2	Guanfacine (Tenex)FDA LinkGeneric 11/2019 - 10/2013
2	lofexidineIBA 11/2019 - 01/2019
2	Minocycline (Cyclops)FDA LinkGeneric 10/2019 - 01/2018
2	CannabinoidsIBA 01/2019 - 10/2018
2	Doxazosin (Cardura)FDA LinkGeneric 01/2019 - 01/2012
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2019 - 01/2018
2	Nerve Growth Factors (Neurotrophins)IBA 01/2016 - 01/2012
2	Interleukin-8 (Interleukin 8)IBA 01/2016 - 12/2008
2	InterleukinsIBA 01/2016 - 12/2008
2	Interleukin-6 (Interleukin 6)IBA 01/2016 - 12/2008
2	Dopamine Receptors (Dopamine Receptor)IBA 11/2015 - 07/2013
2	Proteins (Proteins, Gene)FDA Link 07/2014 - 02/2013
2	Superoxides (Superoxide)IBA 05/2014 - 01/2012
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2014 - 08/2013
2	Dopamine Agonists (Dopamine Agonist)IBA 12/2013 - 04/2002
2	ButyrylcholinesteraseIBA 03/2013 - 03/2013
2	cocaine hydrolaseIBA 03/2013 - 03/2013
2	SmokeIBA 01/2012 - 01/2002
2	Monoamine Oxidase (MAO)IBA 09/2009 - 01/2003
2	Hydrocortisone (Cortisol)FDA LinkGeneric 05/2009 - 04/2002
2	AntibodiesIBA 04/2009 - 01/2005
2	Methylphenidate (Ritalin)FDA LinkGeneric 01/2009 - 04/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2008 - 12/2008
2	Progesterone FDA LinkGeneric 10/2007 - 08/2004
2	Tiagabine (Gabitril)FDA Link 11/2005 - 11/2003
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2004 - 08/2003
2	Desipramine (Pertofrane)FDA LinkGeneric 08/2003 - 01/2002
1	preproenkephalinIBA 06/2022
1	Biological ProductsIBA 03/2022
1	AldehydesIBA 01/2022
1	ziprasidone (Geodon)FDA Link 01/2022
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021

Therapy/Procedure

29	Drug Therapy (Chemotherapy) 03/2022 - 04/2004
12	Therapeutics 06/2022 - 11/2003
7	Immunotherapy 03/2022 - 10/2002
3	Secondary Prevention 11/2019 - 04/2004
2	Nicotine Replacement Therapy 01/2021 - 11/2017